Wound care research has provided a whole spectrum of new and exciting research on basic mechanisms in acute wounds. A poorly understood topic is the susceptibility of skin and underlying tissue to defined noxious insults. Empirical observations suggest that subclinical stress such as pressure may result in tissue damage in most vulnerable patients but not all patients exposed to the same trigger. Clinical scores are commonly employed to predict at-risk populations, yet, more defined parameters are needed to adapt preventive strategies to those patients most in need.
Pressure-induced tissue damage is one area where the general evidence of pressure and tissue damage is very well established. Also, the impact of biomechanics for wound healing are well appreciated. The correlation of biomechanics and the biochemistry and cellular events during normal and impaired wound healing are less explored and offer the potential to identify new treatment targets and more precise definition of at-risk populations.
Here, there is a gap in translational research linking biomechanics, biochemistry, cell biology and structure with clinical parameters. This integrative view has the potential to offer a new treatment options and provide a rationale for clinical implementation beyond current preventive strategies in e..g. pressure-induced tissue damage.